Executive Support Specialist to Massimo Loda, MD
Giorgia Zadra, Ph.D.
Ph.D. in Molecular Oncology at University of Milan Italy, 2007
Dr. Zadra’s research focuses on prostate cancer metabolism to identify specific metabolic vulnerabilities (with a particular attention on lipid metabolism) in primary and advanced prostate cancer that can be exploited therapeutically and/or used as biomarkers for patients stratification as well as novel metabolic tracers for non-invasive molecular imaging in tumor detection and therapeutic response monitoring.
She is specifically interested in:
1) Understanding the metabolic dependencies associated with major genetic alterations found in advanced castration resistant prostate cancer, and how systemic metabolism further affects genetically-driven metabolome reprogramming.
2) Understanding the metabolic underpinning of current resistance to anti-adrogenic therapies in advanced prostate cancer
3) Combining metabolomics and non-invasive approaches of metabolic imaging
Senior Research Technician
Sudeepa is a Senior Research Technician. She is currently involved in projects looking at the effect of high fat diet on prostate cancer and testing new small molecules aimed at inhibiting de novo lipogenesis in using in vitro, xenograft, and GEMM models of prostate cancer.
Habiba Elfandy, M.D.
Research pathologist; PhD candidate, Cairo University
Habiba is investigating and validating prostate cancer molecular fingerprint derived from integrative genomics (SCNV, mutation and gene-expression) linked with certain histomorphologic patterns and their relation to the tumor lethality. Her focus is to describe the key molecular events that may further stratify men into different risk groups under certain histomorphologic patterns and explore their possible therapeutic and prognostic application. She is also contributing specialist expertise to underpin the quality of the ongoing research projects, both in human samples and mice models of prostate disease, for tissues provided from both frozen and FFPEs sources. Her support consists of providing pathology-based specific annotations, interpreting IHC, validating the appropriateness of the tissue samples and providing input on selection of best sections/tumor areas in terms of tumor grade, tissue viability & cellular density prior to the molecular testing and construction of TMAs, ect.
Paolo is a pathology resident from Milan with a special interest in molecular research on cancer.
Caroline is a biochemical engineer who studies the effect of de novo lipogenesis inhibition in prostate cancer cell lines, focusing in intracellular alterations involved with the androgen receptor signaling pathway
Hubert Pakula, Ph.D.
Ph.D. in Molecular Biology at the Humboldt Universität zu Berlin, Germany, 2015
Hubert‘s research interests in the Loda lab are the analysis of cell types of origin for prostate cancer and dissecting the spatio-temporal crosstalk between cancerous epithelial cells and their supporting microenvironment. His studies include the mechanisms of prostate epithelial lineage specification under the androgen-deprivation conditions and generation of organoid models of prostate cancer.
Clinical Research Coordinator
Stephanie Borgstein is the lab’s clinical research coordinator. She is involved in the preparation of grant applications and renewals, oversees IRB protocols, develops databases, and completes laboratory inventory projects.
Student Research Intern
Gianna is a student at Emmanuel College studying biology with a concentration in biochemistry and is set to graduate in May 2018. Gianna is currently working on improving our understanding of IDH1 mutated prostate cancer through multiple molecular platforms and the development of an in vitro IDH1 prostate cancer model.